Eccrine carcinoma histology. Eccrine tumors further divide into benign and .
Eccrine carcinoma histology. Recent Jan 30, 2025 · Purpose of Review Squamoid eccrine ductal carcinoma (SEDC) is a rare and aggressive skin cancer originating from eccrine glands, often misdiagnosed as squamous cell carcinoma (SCC). It occurs most often in older individuals, with a predilection for the lower extremities. Furthermore, therapeutic Feb 8, 2019 · Porocarcinoma is a rare malignant skin tumour that has an aggressive behaviour. The histologic differential diagnoses are microcystic adnexal carcinoma with squamous features, porocarcinoma with squamous differentiation and primary squamous cell carcinoma with ductal differentiation. Aim: To examine the clinicopathological and immunohistochemical features of SEC. It was subsequently expanded to include other organ systems. 1 Eccrine carcinomas usually present as a slow growing infiltrating plaque or nodule on the scalp, extremities, or trunk. [2] Apr 15, 2024 · Squamoid eccrine ductal carcinoma (SEDC) is a cutaneous adnexal malignancy that is histologically challenging to distinguish from squamous cell carcinoma. mitotic figure (arrow) The parameters evaluated concerning prognostic analysis were the following: lymphovascular invasion, perineural invasion, necrosis and the mitotic index. When subsequent clonality testing with archived breast cancer Squamoid eccrine ductal carcinoma is a rare infiltrative tumor with morphologic features intermediate between squamous cell carcinoma (SCC) and sweat gland carcinomas such as microcystic adnexal carcinoma. Keywords: apocrine carcinoma, sweat gland carcinoma, eccrine, apocrine, eccrine carcinoma Introduction Axillary masses present a diagnostic challenge due to the broad range of potential etiologies, including benign and malignant conditions. The histopathology report indicates a lesion typical for cutaneous metastasis of breast carcinoma. We report three cases of this rare entity and review the present literature regarding clinical, histological, and immunohistochemical features. 1, 2 Jan 1, 2014 · Loss of glandular double cell layer as only luminal epithelial cells are present Pleomorphism, nuclear anaplasia, mitotic activity and invasive growth are evident except in well differentiated tumors which may resemble adenomas except for invasive growth Variants include adenoid cystic carcinoma and mucoepidermoid carcinoma Conclusion: Squamoid eccrine ductal carcinoma is a low-grade, highly infiltrative form of eccrine carcinoma with both squamous and ductal differentiation. 1, 2 Jan 1, 2024 · Basaloid squamous cell carcinoma (BSCC) is a subtype of squamous cell carcinoma (SCC) more commonly encountered in mucosal sites including genitalia, oropharynx, and other aerodigestive tract. Authoritative facts from DermNet New Zealand. The tumour forms tubules and glands (figures 2-4) which infiltrate a sclerotic dermis. It presents as a solitary, asymptomatic, slow-growing skin lesion, and may take an aggressive clinical course, with lymph node involvement and distant metastases. Aim To examine the clinicopathological and immunohistochemical features of SEC. atypical elongated cells and central groove, C. [1] It is also known as eccrine porocarcinoma (abbreviated EPC) and malignant eccrine poroma. Consequently, it is sometimes difficult to exclude a metastatic disease [15, 18]. [2] Oct 4, 2021 · Benign and malignant adnexal neoplasm, such as ductal eccrine carcinoma, microcystic carcinoma and papillary digital eccrine carcinoma: Key difference is the striking variegation of histologic growth patterns seen in polymorphous sweat gland carcinoma that would not be seen in other adnexal neoplasms Feb 4, 2013 · Eccrine carcinoma is an extremely rare malignancy of the skin with few well documented cases reported in the literature. 01% of diagnosed cutaneous malignancies. Jan 1, 2004 · Cutaneous eccrine and apocrine glands have many histologic and immunologic similarities to ducts and acini of the breast. Here, we report a case of suspected eccrine adenocarcinoma in a dog. It emphasises the importance of recognising such tumours for appropriate management Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm originally believed to be of eccrine origin. duct formation, D. To the Editor: Eccrine carcinoma (ECC), first described in 1865, is a rare skin tumor accounting for less than 0. Its name originates from histological pat- tern which resembles that one of a syringoma by showing ductal, cystic, and comma-like epithelial components in a fibrocollagenous matrix. Furthermore, many eccrine/apocrine lesions coexist within hamartomas or within Nov 30, 2021 · Basal cell carcinoma with eccrine differentiation: Peripheral palisading and no cystic areas Stromal epithelial retraction Epidermal connection Hidradenocarcinoma: Greater cytologic atypia, mitoses and infiltrative Squamous cell carcinoma: Epidermal connection, keratin pearls and infiltrative Absence of secretory differentiation Trichilemmoma: Feb 27, 2020 · Background: Sweat gland carcinomas divide into eccrine, apocrine, mixed origin (eccrine and apocrine). However, diagnostic imaging excludes recurrent breast cancer or metastatic spread. Given the rarity of these tumors, no known criteria by which to diagnose the tumor or guidelines for treatment have been pro-posed. Eccrine differentiation is readily seen at high power (best seen in figures 2 and 3). Eccrine carcinoma is an extremely rare neoplasm of the eccrine sweat glands; it has a slow rate of growth and a high potential for recurrence. Eccrine carcinoma (EC) is a rare malignant neoplasm of the sweat glands that can affect dogs, cats, and humans. Recently, several gene alterations have been reported in PC that can reveal mechanisms of the Nov 1, 2024 · Squamoid eccrine ductal carcinoma is a rare infiltrative tumor with morphologic features intermediate between squamous cell carcinoma (SCC) and sweat gland carcinomas such as microcystic adnexal carcinoma. 6 Eccrine adenomas and adenocarcinomas have been documents in dogs, while eccrine tumors are usually malignant in cats. We report a rare case of an immunocompromised patient with a primary squamoid eccrine ductal carcinoma (SEDC) who was subsequently Apr 22, 2022 · Pathophysiology Ultrastructural finding (see below) and eccrine glands are abundant in acral sites This is because digital papillary adenocarcinoma is an eccrine tumor How does eccrine porocarcinoma present? Eccrine porocarcinomas are typically slow-growing tumours. Background: Squamoid eccrine ductal carcinoma (SEDC) is a rare cutaneous adnexal tumor originating from the eccrine apparatus, characterized by a biphasic differentiation pattern on histopathology. PC was first reported in 1963 by Pinkus and Mehregan, who referred to it as “epidermotropic eccrine carcinoma Eccrine porocarcinoma, also known as malignant eccrine poroma, is a rare sweat gland neoplasm which presents as verrucous plaques or polypoid growths. Apr 15, 2015 · Eccrine carcinomas are uncommon cutaneous neo-plasms demonstrating nonuniform histologic fea-tures, behavior, and nomenclature. 2 The lesions typically present as erythematous, asymptomatic nodules measuring 0. 4 While a common disease in humans, eccrine glands are confined to the footpads of dogs and cats, and this is the only site at which eccrine neoplasia occurs. Generally, they are composed of luminal cells and basal type Mar 19, 2020 · Case description: A seventy-year-old woman previously treated definitively for (in situ) breast cancer, undergoes excision of a nodule on the scalp. Introduction Malignant cutaneous adnexal tumors (MCATs) are broadly divided into four groups: eccrine, apocrine, mixed, and un-classified. EC is more common in elder animals, and exhibits no predisposition according to breed. Dec 10, 2024 · Skin nonmelanocytic tumor Adnexal tumors Sweat gland derived (apocrine & eccrine glands) Primary cutaneous mucinous carcinoma Abstract Squamoid eccrine ductal carcinoma is a poorly documented skin adnexal carcinoma showing squamous and duct differentiation. Cuta-neous clear cell squamous cell carcinoma (cccSCC) is a variant of squamous cell carcinoma marked by intracellular glycogen accumula-tion, clear cell differentiation, and a clinical This case study presents an unusual case of a low-grade eccrine carcinoma showing squamous differentiation. Recent Jun 26, 2023 · Eccrine carcinoma (EC) is a rare carcinoma that originates from the eccrine sweat glands of the skin and accounts for less than 0. This comprehensive guide aims to enhance your diagnostic skills by focusing on practical pathology education, covering It was firstly described as “epidermotropic eccrine carcinoma” by Pinkus and Mehregan in 1963, while a few years later, Mishima and Morioka addressed the term “eccrine porocarcinoma”, which is now most frequently used and was included in the 2018 World Health Organization (WHO) classification of skin tumors [2, 3, 4]. Eccrine carcinoma There are three types of sweat glands in the human body: eccrine, apocrine, and apoeccrine. Sep 26, 2019 · Squamoid eccrine ductal carcinoma is a low-grade, biphasic malignant sweat gland tumor showing areas resembling well- to moderately differentiated squamous cell carcinoma in the superficial Jun 2, 2021 · Benign tumor with debated origin from eccrine sweat glands or hair follicles; Also called turban tumor, particularly when a large, multicentric scalp tumor Sweat gland lesions, Tumours of apocrine sweat glands, Tumours of eccrine sweat glands. The differential diagnosis includes metastases from internal malignancies, basal cell carcinoma, and other benign and malignant adnexal neoplasms such as adenoid cystic carcinoma, ductal eccrine carcinoma, and microcystic carcinoma. Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare, low-grade adnexal neoplasm with predilection for the periorbital skin of older women. S100 is a marker for eccrine neoplasia negative in apocrine neoplasia; p63, ER, and GCFP15 are markers for eccrine neoplasia. Oct 8, 2022 · Eccrine porocarcinoma, also known as porocarcinoma (PC) and malignant eccrine poroma, is very rare and is known to arise from the cutaneous intraepidermal ducts of the sweat glands. We report the thirteenth case of squamoid eccrine ductal carcinoma. 1 These tumors are slow growing, arising on the face (particularly the eyelids), axilla, scalp, and trunk of middle-aged and older individuals. The tumor cells are diffusely and strongly positive for AR and AMACR; they are Histology of primary mucinous eccrine carcinoma often mimics metastatic carcinoma of breast or gastrointestinal tract origin. diffuse infiltrative pattern, B. Eccrine tumors further divide into benign and Histology of eccrine carcinoma Sections of eccrine carcinoma show a tumour composed of basaloid cells infiltrating the dermis (figure 1). This report discusses two unique cases of eccrine carcinoma in middle-aged females, occurring at atypical locations: the thigh and the anal region. Histology of primary mucinous eccrine carcinoma often mimics metastatic carcinoma of breast or gastrointestinal tract origin. Because of super-ficial sampling, SEDC Mar 27, 2025 · Background: Squamoid eccrine ductal carcinoma (SEDC) is an exceedingly rare and aggressive cutaneous adnexal malignancy, with fewer than 100 reported cases. It is a rare tumor and its histopathological diagnosis is difficult. Despite its Introduction Eccrine spiradenocarcinoma is a rare sweat gland tumour. Sep 26, 2019 · Squamoid eccrine ductal carcinoma is a low-grade, biphasic malignant sweat gland tumor showing areas resembling well- to moderately differentiated squamous cell carcinoma in the superficial Jun 2, 2021 · Benign tumor with debated origin from eccrine sweat glands or hair follicles; Also called turban tumor, particularly when a large, multicentric scalp tumor Jan 2, 2016 · Eccrine spiradenoma, also spiradenoma, [1] is (usually) a benign, painful skin thingy. Methods Four cases were reviewed by three dermatopathologists and the immunohistochemical profile was examined using antibodies against CK5/6, CK7, CK14, CK20, LMWK, HMWK, EMA, mCEA, p63, ER, PR, AR, S-100 Jan 1, 2020 · Background: Sweat gland carcinomas divide into eccrine, apocrine, mixed origin (eccrine and apocrine). Papillary glandular neoplasm (see comment) Margins negative for tumor Comment: The findings are consistent with a papillary eccrine adenoma (also called Participants also discussed the various histologic variants of apocrine adenocarcinoma mentioned above by the contributor. Jan 1, 2014 · Loss of glandular double cell layer as only luminal epithelial cells are present Pleomorphism, nuclear anaplasia, mitotic activity and invasive growth are evident except in well differentiated tumors which may resemble adenomas except for invasive growth Variants include adenoid cystic carcinoma and mucoepidermoid carcinoma Conclusion: Squamoid eccrine ductal carcinoma is a low-grade, highly infiltrative form of eccrine carcinoma with both squamous and ductal differentiation. Mar 12, 2024 · Microcystic adnexal carcinoma is a rare, malignant adnexal tumor with sweat duct and follicular differentiation. Histology of eccrine spiradenocarcinoma In eccrine spiradenocarcinoma, sections show areas of benign eccrine spiradenoma with an abrupt transition in morphology (figures 1, 2). Porocarcinoma (PC) is an uncommon and aggressive skin cancer that originates in the intraepidermal component of the sweat gland apparatus [1]. A. Furthermore, therapeutic Jan 1, 2020 · Squamoid eccrine ductal carcinoma is a low-grade, biphasic malignant sweat gland tumor showing areas resembling well- to moderately differentiated squamous cell carcinoma in the superficial aspects and eccrine ductal carcinoma in the deeper reaches of the tumor [25]. [1]: 669 It originates from the eccrine sweat glands of the skin, accounting for less than 0. Archival materials of all benign, atypical, and malignant hidradenomas, and metas-tasizing adnexal carcinomas, including eccrine ductal carcinoma and apocrine carcinomas diag-nosed between 1987 and 2008, were retrieved from the pathology files of the Massachusetts General Hospital (Boston, MA). 2 - 4 Multiple subtypes of eccrine carcinoma are classified by their distinct histological pattern. It can take many years before a diagnosis is made because eccrine porocarcinoma can mimic other skin conditions. Analogous to normal sweat glands, eccrine and apocrine gland tumors have the same cell components. Eccrine differentiation is The histopathology of mucinous eccrine carcinoma of the skin is analogous to that of its counterpart in the breast. Â Several raised the possibility of apocrine ductal carcinoma; the moderator pointed out that there should be foci of squamous differentiation in addition to a double-layer of neoplastic epithelial cells, both of which are Jun 15, 2025 · Eccrine carcinoma is a rare and complex skin malignancy that originates from the eccrine glands, which are a type of sweat gland. Feb 6, 2024 · Eccrine syringofibroadenoma is a rare, benign eccrine proliferation of anastomosing cords with ductal structures set in a fibrovascular stroma, often located on the extremities. Clear cell change may be seen Sep 16, 2005 · The histopathology of mucinous eccrine carcinoma of the skin is analogous to that of its counterpart in the breast, comprising nests of variably cohesive atypical epithelia lying free in pools of mucin. Sweat gland derived (apocrine & eccrine glands): adenocarcinoma of mammary-like glands of vulva adenoid cystic carcinoma (primary cutaneous) apocrine carcinoma cutaneous adnexal NUT carcinoma cutaneous mixed tumor / chondroid syringoma cylindroma digital papillary adenocarcinoma spiradenoma eccrine syringofibroadenoma endocrine mucin producing Sweat gland lesions, Tumours of apocrine sweat glands, Tumours of eccrine sweat glands. In questionable cases immunohistochemistry can be used to distinguish SEDC from squamous cell carcinoma. Eccrine carcinoma is a rare tumour that typically presents as a slow growing plaques or nodules on the scalp but can arise at other sites. Its histopathologic overlap with squamous cell carcinoma (SCC) frequently leads to misdiagnosis, delaying appropriate management. Almost half of patients are misdiagnosed as squamous cell carcinoma by the incisional biopsy. Clear cell change may be seen Squamoid eccrine ductal carcinoma (SEDC) is a rare and under-recognized primary cutaneous tumor with a high risk for local recurrence and metastasis. The tumor has a biphasic histologic appearance consisting of a superficial portion indistinguishable from squamous cell carcinoma (SCC) and a deeper component demonstrating eccrine ductal differentiation. Although currently classified as a sweat gland carcinoma, it has been debated whether squamoid … Squamoid eccrine ductal carcinoma is a diagnostic challenge, as it is an eccrine gland tumour histologically resembling squamous cell carcinoma superficially, and deeper tissue sampling is needed to reveal ductal differentiation. The initial tumor was Jun 26, 2023 · Eccrine carcinoma (EC) is a rare carcinoma that originates from the eccrine sweat glands of the skin and accounts for less than 0. 1. Background Syringoid eccrine carcinoma (SEC) is a rare malignant adnexal tumour with variable presentations. It usually occurs in the head and neck, in the face, eyelids and scalp. Unlike SCC, SEDC exhibits biphasic differentiation, deep infiltration, and a high rate of perineural invasion Apr 6, 2023 · Left breast, partial mastectomy: Carcinoma with apocrine differentiation (see synoptic report and comment) Comment: Sections show an infiltrating tumor comprised entirely of large epithelial cells with abundant eosinophilic and granular cytoplasm, well defined cell borders, enlarged nuclei and prominent nucleoli. This review aims to synthesize existing data on SEDC epidemiology, pathophysiology, clinical manifestations, diagnosis, histopathology, immunohistochemistry, treatment approaches, prognosis, and follow-up. Eccrine carcinoma is a rare skin condition characterized by a plaque or nodule on the scalp, trunk, or extremities. Apr 27, 2022 · Syringoid eccrine carcinoma (SEC) is an extremely rare malignant adnexal tumor with eccrine differentiation first described by Freeman and Wilkemann in 1969 as eccrine epithelioma [1]. It is frequently found on the lower extremities, and it equally affects both sexes in the sixth and seventh decade. . The malignant areas can be carcinomatous or Jun 26, 2023 · Point of Care - Clinical decision support for Eccrine Carcinoma. Histology of SEDC shows duct-like structures resembling eccrine ducts and clusters of atypical squamous cells. The tumor has a biphasic histologic appearance consisting of a superficial portion indistinguishable from squamous cell carcinoma (SCC) and a deeper c … Sep 29, 2020 · Skin nontumor - Basic skin histologySkin is the largest organ of the body with a weight of approximately 5 kg and an area close to 2 m² General functions of the skin: Protection (against UV light, dehydration, microbial invasion, mechanical injury, chemical and thermal stresses) Retains water and excretes drugs and waste Thermoregulation through blood vessels and eccrine glands Metabolic Sep 28, 2021 · Benign adnexal neoplasm of sweat gland (eccrine) origin; most common clinical presentation on lower eyelids of women; appears to derive from sweat duct ridge; malignant counterpart can be termed syringomatous carcinoma / sweat gland carcinoma According to past reports, eccrine adenocarcinoma is an aggressive tumor showing metastasis to lymph nodes [1]. Eccrine tumors further divide into benign and Histology of SEDC shows duct-likestructuresresemblingeccrineductsandclustersofatypicalsquamouscells. The most frequent described presentation has been a slow-growing dermal mass arising on the head and neck of older adults. It is regarded to be of low-grade malignant potential, but limited follow-up information is available. 4 ,5 It is considered to have higher risk for locoregional recurrence and metastasis compared to conventional squamous cell carcinoma. Treatment and management. Squamoid eccrine ductal carcinoma (SEDC) is a rare malignant cutaneous neoplasm that is biphasic on histopathology, with both squamous (tumor surface) and ductal eccrine (tumor depth) differentiation, often being confused with squamous cell carcinoma (SCC), especially in superficial biopsies. Sweat gland tumors have traditionally subdivided into four broad groups: eccrine, apocrine, mixed origin (eccrine and apocrine), … Squamoid eccrine ductal carcinoma is an eccrine carcinoma subtype, and only twelve cases have been reported until now. Histologic examination remains the most important diagnostic tool for SEDC. In all, 10–34% of breast carcinomas overexpress HER-2 protein, a membrane-associated protein that functions in cell differentiation, adhesion and motility. Cutaneous hidradenocarcinoma is a rare malignant neoplasm, originating from the eccrine sweat glands, and corresponding to 6% of the eccrine malignant tumors. 01% of cutaneous appendageal carcinomas. Dec 2, 2024 · Abstract Malignant cutaneous clear cell tumors encompass a diverse range of rare skin neoplasms characterized by clear cell morphology, which can be of epidermal, adnexal, mesenchymal, or melanocytic origin. Its etiology is not well understood; however, some studies suggest that PC tumors originate from benign eccrine poroma. It creates diagnostic confusion, especially when located at axillary area. It was launched in 2003 by Dr. The mitotic index was analyzed qualitatively, and the cutoff for high or low Cutaneous hidradenocarcinoma is a rare malignant neoplasm, originating from the eccrine sweat glands, and corresponding to 6% of the eccrine malignant tumors. Its superficial component resembles well-differentiated squamous cell carcinoma (cSCC), while the deeper component exhibits infiltrative features with prominent ductal differentiation. Histologically and immunophenotypically, EMPSGC is analogous to another neoplasm with Squamoid eccrine ductal carcinoma (SEDC) is a rare and under-recognized primary cutaneous tumor with a high risk for local recurrence and metastasis. Furthermore, therapeutic Eccrine Porocarcinoma – Histology. Dharam Ramnani, with an initial focus on urologic pathology. Jan 24, 2023 · Skin nonmelanocytic tumor - Syringocystadenoma papilliferum is a benign, hamartomatous, adnexal tumor that originates from the apocrine or the eccrine sweat glands May 1, 2014 · Homologous carcinomas of the breasts, skin and salivary glands: a histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma and salivary duct carcinoma Apr 1, 2022 · Abstract Background: Squamoid eccrine ductal carcinoma (SEDC) represents a subtype of eccrine carcinomas that are diagnostically challenging for both clinicians and dermatopathologists. Eccrine carcinoma (EC) is a rare malignant neoplasm of the sweat glands that can affect dogs The positivity for chromogranin and CD56 suggests partial neuroendocrine differentiation. Histology of eccrine carcinoma Sections of eccrine carcinoma show a tumour composed of basaloid cells infiltrating the dermis (figure 1). The initial tumor was Feb 4, 2013 · Eccrine carcinoma is an extremely rare malignancy of the skin with few well documented cases reported in the literature. Aug 6, 2021 · Tumours of cutaneous sweat glands are uncommon, with a wide histological spectrum, complex classification and many different terms often used to describe the same tumour. Primary eccrine carcinoma, sy An important differential to consider is eccrine gland carcinoma. Primary cutaneous mucinous carcinoma (PCMC) is a rare adnexal malignancy arising from eccrine glands. However, there have been few reports concerning this malignancy in dogs, so the pathology, pathogenesis, diagnosis, and treatment are largely unclear. Squamoid eccrine ductal carcinoma is a rare infiltrative tumor with morphologic features intermediate between squamous cell carcinoma (SCC) and sweat gland carcinomas such as microcystic adnexal carcinoma. There is case series of malignant ones. [1] Sweat gland tumors have traditionally subdivided into four broad groups: eccrine, apocrine, mixed origin (eccrine and apocrine), and other unclassifiable sweat gland tumors. Thus, differentiating a primary cutaneous process from a metastatic breast carcinoma can be nearly impossible. 01% of all cutaneous tumors. 5 to 7 cm in diameter; however, larger Jun 26, 2023 · Eccrine carcinoma (EC) is a rare carcinoma that originates from the eccrine sweat glands of the skin and accounts for less than 0. It typically arises within a pre-existing eccrine spiradenoma that has been present for many years. In humans Eccrine carcinomas, originating from the eccrine glands, are rare, comprising <0. [2] Eccrine carcinoma is a rare skin adnexal tumour that presents significant diagnostic challenges due to its uncommon occurrence and varied clinical presentations. Hematoxylin Jan 30, 2025 · Purpose of Review Squamoid eccrine ductal carcinoma (SEDC) is a rare and aggressive skin cancer originating from eccrine glands, often misdiagnosed as squamous cell carcinoma (SCC). 1-3 ECC presents as a solitary, locally invasive, slow growing, nonencapsulated, nontender nodule, most commonly on the head and neck or extremities with low risk for metastasis and lymph node involvement. Although currently classified as a sweat gland carcinoma, it has been debated whether squamoid eccrine ductal carcinoma is better classified as a variant of SCC. [14] Here, we report a rare case of primary mucinous eccrine carcinoma of axilla in a 65-year-old male. The histologic differential diagnoses are microcystic adnexal carcinoma with squamous features, porocarcinoma with squamous differentiation and primary squamous cell carcinoma with ductal differentiation. In our case, we present a 46- year-old female with a recurring exophytic tumor on the right lower extremity, without local extension. 2,4 Ultraviolet radiation The histologic findings, together with immunoperoxidase and enzyme histochemical studies, usually allow differentiation between eccrine carcinomas, other cutaneous neoplasms, and visceral adenocarcinomas with skin metastases. As Abstract Background: Syringoid eccrine carcinoma (SEC) is a rare malignant adnexal tumour with variable presentations. Primary cutaneous mucinous carcinoma is a distinctive tumour that has been variously described as apocrine and eccrine. Squamoid eccrine ductal carcinoma often deeply infiltrates within the dermis and, in up to 70% of cases, extends into the subcutaneous tissue. Histology of mucinous carcinoma In mucinous carcinoma, there is a dermal mass composed of glands and solid nests of epithelial cells which appear to be Sep 29, 2020 · Positive stains Neuroendocrine expression: NSE, synaptophysin, chromogranin, CD56, INSM1 Mucicarmine highlights intracellular and extracellular mucin CK7, ER / PR, GCDFP-15 and GATA3 (Am J Dermatopathol 2016;38:789) are also positive in adenocarcinoma of breast and salivary gland and cannot distinguish it from endocrine mucin producing sweat gland carcinoma Calponin, SMA and p63 highlight May 21, 2021 · Sample pathology report Skin, right foot, excision: Papillary glandular neoplasm (see comment) Margins negative for tumor Comment: The findings are consistent with a papillary eccrine adenoma (also called papillary adenocarcinoma in situ). Feb 18, 2025 · Several eccrine carcinoma subtypes bear histologic resemblance to a well-described benign counterpart; these tumors are named accordingly, and the microscopic distinction between benign and malignant usually is made based on extent of invasion, asymmetry at scanning magnification, and degree of nuclear atypia. Jan 18, 2024 · Cytokeratin profile, p63/p40, CEA, EMA, CD15, GATA-3, S100, ER, PgR, androgen receptors, and GCFP-15. Introduction, Etiology, Epidemiology, Histopathology, History and Physical, Evaluation, Treatment / Management, Differential Diagnosis, Staging, Prognosis, Complications, Deterrence and Patient Education, Enhancing Healthcare Team Outcomes Apocrine carcinoma Apocrine/eccrine hidrocystoma, cystadenoma Hidroacanthoma simplex (intraepidermal poroma), eccrine poroma, dermal duct tumor Nodular hidradenoma, solid-cystic hidradenoma, clear cell hidradenoma, clear cell acrospiroma, eccrine acrospiroma Papillary eccrine adenoma, tubular apocrine adenoma, papillary apocrine fibroadenoma Papillary syringoadenoma Papillary hidradenoma Jan 17, 2006 · The histopathology of mucinous eccrine carcinoma of the skin is analogous to that of its counterpart in the breast, comprising nests of variably cohesive atypical epithelia lying free in pools of May 22, 2023 · Squamoid eccrine ductal carcinoma is a rare infiltrative tumor with morphologic features intermediate between squamous cell carcinoma (SCC) and sweat gland carcinomas such as microcystic adnexal carcinoma. WebPathology is an educational resource with high quality pathology images of benign and malignant neoplasms and related entities. EC can present itself as a solitary swelling in the pads, digits, or distal limbs. To study their clinical behavior and histologic features, 30 squamoid eccrine ductal carcinomas were identified from departmental and referral files. It is often misdiagnosed as seborrhoeic keratosis, pyogenic granuloma, viral wart (verruca) or squamous cell carcinoma. The differential diagnosis for mucinous carcinoma clinically would also include other benign and malignant eccrine tumors, sebaceous carcinoma, cystic basal or squamous cell carcinoma, epidermoid cyst, pyogenic granuloma, hemangioma, Kaposi’s sarcoma, neuroma, or pilomatrixoma [100]. Diagnosing eccrine carcinoma can be challenging due to its diverse histological features and the need to differentiate it from other skin tumors. etyt7kbfaex38vhh4rrh7hibqc6zomxzqcuvgms0nmy9od